Has there been any further desigantion for the G-pos band
 that resolves within 8p23.1 at >550 bphs?

Is there, or will there be, a cd-rom for the ISCN?  This would be helpful as we attempt to interpret for data analysis.

Thank you.

Dear sir/Madam,

I would like to ask about the most recent publications of the ISCN and how much dose it cost?
Is there, a CD-rom for the ISCN?.

In looking forwards to hearing from you soon, please accept my most sincere regards

Dr Ashraf Ibrahim Msc. 
Associate researscher
Human Cytogenetic Department
National Reseaech Center
Eltahrir st., Eldokki
Cairo, 
EGYPT 

Dear sir/Madam,

I would like to ask about the most recent publications of the ISCN and how much dose it cost?
Is there, a CD-rom for the ISCN?.

In looking forwards to hearing from you soon, please accept my most sincere regards

Dr Ashraf Ibrahim Msc. 
Associate researscher
Human Cytogenetic Department
National Reseaech Center
Eltahrir st., Eldokki
Cairo, 
EGYPT 

I would like to ask about the most recent publications of the ISCN and how much dose it cost?
Is there, a CD-rom for the ISCN?.

In looking forwards to hearing from you soon, please accept my most sincere regards

Dr Ashraf Ibrahim Msc. 
Associate researscher
Human Cytogenetic Department
National Reseaech Center
Eltahrir st., Eldokki
Cairo, 
EGYPT 

It would be very useful to have the digitized ideogram data (Francke Cyto Cell Genet 65:206-219, 1994) available from this web site.

thank you,

Norman Doggett, Ph.D.
Los Alamos National Laboratory

terfgd yyhh mkk ,,,, lll

I would like to have more information about the latest development in the ISCN 1995. Please let us know about any new modification for this system. I would be most grateful if you kindly agree to involve me in your great mission to enrich the field of cytogenetics
Best regards

Professor Nahi Yousif Yaseen
PhD cancer cytogenetics, Sheffield University, UK.
Director General
Iraqi Centre for Cancer and Medical Genetics Research
Baghdad
Iraq 

Dear Prof. Tommerup, 

I have a question concerning the description of gains of derivate chromosomes resulting from a threeway translocation. Which karyotype would you consider to be correct:

46,XY,t(9;22;1)(q34;q11;q25),+der(9)t(9;22;1)(q34;q11;q25),+der(22)t(9;22;1)(q34;q11;q25)
or
46,XY,t(9;22;1)(q34;q11;q25),+der(9)t(1;9)(q25;q34),+der(22)t(9;22)(q34;q11)

I´d prefer the second version, because in each derivative chromosome only two chromosomes are involved.

Thank you for your help!

Best regards,

Harald Rieder

When will there be a new ISCN out as this one is nearly ten years old?

Dear dr.

I\'m a domenstrator at el minia Univ. Egypt and I want please:
the steps to makeing G-banding for bone marrow (arvicanthis)
thanks too much sir 
waiting replay at My E-mail

Dear Mr/Mrs,

I\'m from Brazil and in this year I\'m training in VUB - Brussels. 
I would like to know about the most recent publications of the ISCN and how much does it cost? 
Is there, a CD-room for the ISCN?.
Can I order it by internet and to receive it in Brussels until november?

Best Regards,

Laura Vagnini
Human Reproduction Center - Maternidade Sinha Junqueira
Adress: Dom Alberto Gonçalves, 1500 Campos Eliseos
Ribeirão Preto - SP - Brasil
CEP: 14085-100
Phone: 55-16-6262909
home-page: http://www.crh.com.br

 

Hi,

Would some one help me to find out were to buy the book mentioned in title line? The ISBN for this book is 3-8055-6226-8.

Thank you so much

Sumaya.
Ottawa, Canada.

Please, what is wrong with
46,XY,22stk+ ?
How must be written a big satellite in 22p?
Thank you very much

Dr. Roberto Ruiz
Citogenética
Hospital San Millán
Logroño (SPAIN)

It would be very useful to have the digitized ideogram data
i also need a explianation of the data 
where will i get it 
please help
i am student doing my pg progect.

Since each previous ISCN has clarified nomenclature issues from the decriptions in previous ones, it might help you organize the next to know specifically where the 1995 version is unclear.

Specifically, any lab trying to describe complex karyoytpes (especially in neoplasms or cell lines) has come across chromosomes or rearrangements that can be recognized, but not unambiguously described with the current nomenclature. Or, even with the wealth of examples shown and described in ISCN 1995, there is some question remaining of how to apply a particular description.

Please consider a *well-publicized* online invitation to cytogeneticists to submit their difficult chromosomes/rearrangements/questions that the current ISCN fails to address sufficiently. For reasons of patient privacy and (in some cases) pre-publication data, the submissions should be visible only to the committee.

Looking forward to ISCN 2005,
Anit L. Hawkins
Johns Hopkins Pathology Cytogenetics
Baltimore, Maryland, USA

I\'m finding a profound lack of reference material for dealing with ISCN karyotypes. While I can find some description of the terms, others are missing (at least compared to the Mitelman database), and I cannot find documentation of the syntax (just the abbreviations).

As far as I can tell, there is no reference implementation of a parser or syntax checker that\'s readily available in source form, and there\'s not even a published grammar available for download.

It might be nice if this site either had those things or had references to where one might find them...

To the ISCN Committee,

I think an online or CD version of the ISCN is well over due.  Moreover, the new edition should include revised guidelines that address karyotypic descriptions revealed by 24-colour FISH, particularly in cancer cytogenetics. 

The new edition may also want include a Reviews Section on the advances of (Molecular) Cytogenetics and disucss such topics such as FISH (interphase FISH and metaphase FISH including MFISH/SKY), FISH scoring criteria for deletions, amplification etc., CGH, array CGH, digital kartyotyping, etc.

There is also and increasing demand for mouse and rat cytogenetics.  It would be very beneficial to provide ideograms and guidelines of rodent studies.


Jane Bayani, BSc. MHSc.
Department of Cellular and Molecular Biology
Ontario Cancer Institute, Princess Margaret Hospital.
University of Toronto.
Toronto, Canada
http://www.utoronto.ca/cancyto/

Dear Recepient,

I have recently try to figure out the meaning of the cytogenetical nomenclature and coding to describe karyotypes. So far reuseable descriptive explanation could be rarely found in the WWW. In fact, there are many exceptions in the literature that is not covered or discribed at all. I tried to click on KaryotypeSyntax on this site to get help and also checked with OldKaryotypeChecker but none actually helped. So for example, what does a number in brackets mean:

45,X[128]
46,X,+idic(Y)(p11.32)[65]

or a percentage notation:

add(7)(q31)x2,t(8;21)x2(7%)
45,X,-Y,t(8;21)(15%)

I hope I can find some help soon through ISCN here

cheers

kevin

I would like to question on a karyotype though it is not good at English.
When it is possible to answer, it is glad.  

Q1 Normal 13 is not. dic(13;13)(q14;q32) is one. �¨ 45,XX,dic(13;13)(q14;q32) OK
  If  Normal 13 is one. and dic(13;13)(q14;q32) is one.�¨�@
                  46,XX,dic(13;13)(q14;q32)  or 46,XX,+13,dic(13;13)(q14;q32) 
            Which is correct answer it?

Q2 Normal 13 is one. and idic(13)(q32) is one. �¨ 46,XX,idic(13)(q32) OK 
  If  Normal 13 is not.and idic(13)(q32) is one. �¨ 
                45,XX,idic(13)(q32) or 45,XX,-13,idic(13)(q32)
            Which is correct answer it?

Q3 Normal 13 is one. and i(13)(q10) is one. �¨ 46,XX,i(13)(q10) OK 
  If  Normal 13 is not.and i(13)(q10) is one. �¨ 
                45,XX,i(13)(q10) or 45,XX,-13,i(13)(q10)
            Which is correct answer it?

  In addition, can a [i(13)(q10)]be changed into  [der(13;13)(q10;q10)]?

  
Q4 Normal 17 is one. and i(17)(q10) is one. �¨ 46,XX,i(17)(q10) OK 
  If  Normal 17 is not.and i(17)(q10) is one. �¨ 
                45,XX,i(17)(q10) or 45,XX,-17,i(17)(q10)
            Which is correct answer it?

My best regards above though they are four questions.    
thank you so much sir 
I will sincerely wait for the answer at My E-mail.      

TOKYO,
JAPAN
 

Sorry to bother at this point. But I have been trying to understand what the following karyotypes means using ISCN1995 booklet. In particular I cannot find a definition or explaination of using:
2D-, D+, Cp+ nor G+

I assume the encoding I read is correct, since it is published as is in PubMed (see below).

please need help.

kev


PubMed: 4244360
Clinical and longitudinal cytogenetic study of a case of 46,XX-47,XX,G+ mosaicism (trisomy 21) 

PubMed: 4901160
Monoclonal abnormal karyogram: 45,XX,2D-,(17-18)-


PubMed: 5410414
Polydactyly and other minor stigmata associated with 46,XX-47,XX,D+ mosaicism


PubMed: 5308379
46,XY-47,XY,C+ mosaicism in a male infant with multiple anomalies


PubMed: 5365588
Familial 2-C translocation: 46,XYt(2p-;Cp+) and 46,XXCp+ 

There is no saying division on your precious time.
It is a person who was going to question on the karyotype type description before.
I would like to boil, and question on the answer bulrush again.
My best regards because of really embarrassing it on our inspection site.

Q1 Normal 13 is not. dic(13;13)(q14;q32) is one. = 45,XX,dic(13;13)(q14;q32) OK
  If  Normal 13 is one. and dic(13;13)(q14;q32) is one.=�@
                  46,XX,dic(13;13)(q14;q32)  or 46,XX,+13,dic(13;13)(q14;q32) 
            Which is correct answer it?

Q2 Normal 13 is one. and idic(13)(q32) is one. = 46,XX,idic(13)(q32) OK 
  If  Normal 13 is not.and idic(13)(q32) is one. = 
                45,XX,idic(13)(q32) or 45,XX,-13,idic(13)(q32)
            Which is correct answer it?

Q3 Normal 13 is one. and i(13)(q10) is one. = 46,XX,i(13)(q10) OK 
  If  Normal 13 is not.and i(13)(q10) is one. = 
                45,XX,i(13)(q10) or 45,XX,-13,i(13)(q10)
            Which is correct answer it?

  In addition, can a  [i(13)(q10)] be changed into  [der(13;13)(q10;q10)]?

Q4 Normal 17 is one. and i(17)(q10) is one. = 46,XX,i(17)(q10) OK 
  If  Normal 17 is not.and i(17)(q10) is one. = 
                45,XX,i(17)(q10) or 45,XX,-17,i(17)(q10)
            Which is correct answer it?

My best regards above though they are four questions.    
thank you so much sir 
I will sincerely wait for the answer at My E-mail.      

TOKYO,
JAPAN

46,XY,22p+.ish der(22)t(20;22)(pter→q10;pter) [WCP20+++,WCP22++,PCP20+++,Tel20pter+++) 

Where I can buy the latest ISCN book?

If one would have a female karyotype with an der(21) formed by the joining of the qter regions of two 21, plus one normal 21, would the correct nomenclature be (understanding that one centromere of the idic(21) is deleted at p11.1):

46,XX,der(21)idic(21)(q22.3)del(21)(p11.1)
or
46,XX,der(21)idic(21)(q22.3)del(21)(p11.1),+21
?
I was wondering because if it were a robertsonian der(21;21)(q10;q10), then +21 would be used to indicate three copies of chromosome 21.

Please:

I am a medicine student and need this article for anlyses in class.
or you can tell me what is the page

tanks 

Washington 

There is a fetal karyotype with 46 chromosomes with a distinct p arm in one of 14, which was confirmed 21 by FISH. Two normal 21s are present. How will be karyotype written? Is 46,XX,14p+,+21,t(14;21) correct? Kindly guide me.

When is this site going to be renamed 'ISCN 2005'?

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Can you tell me exactly what this karyotype means 46,XX,der(21;21)(q10;q10). I had an amnio & this is what the result of it was. Thanks!!!!!!!!!!

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